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Smoking can exacerbate allergic reactions by increasing sensitivity to allergens

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9 Compared to the most recent population figures for current smokeless tobacco use among United States adult females (0.3%), smokeless tobacco use was significantly under-reported in the sample of adult females 18 to 80 years with a unilateral open tibia fracture with one year of follow-up within the database (10 of 6,999, 0.1%) (z-statistic = -2.41, one-tailed p-value = 0.01)

However, the success rate of this approach ranges from 22% to 27%, or as low as 3% to 5% in some cases