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Although the role of NKCC2 in renal handling of glucose remains poorly defined, NKCC2A KO mice developed several aspects of MetS including increased basal glycemia, glucose intolerance and insulin resistance (Kelly et al., 2019), but not hypertension, at least when mice were young (Oppermann et al., 2007)

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In sepsis-induced cardiomyopathy, apoptosis and pyroptosis are not isolated events but share a common upstream regulatory pathway: the STINGIRF3NLRP3 axis