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The activated receptor phosphorylates insulin receptor substrate-2 (IRS-2), which in-turn activates the RAS activating protein SOS

10.1111/imr.13379 [DOI] [PMC free article] [PubMed] [Google Scholar] 24.Mazor Y, Oganesyan V, Yang C, Hansen A, Wang J, Liu H, Sachsenmeier K, Carlson M, Gadre DV, Borrok MJ, Yu XQ, DallAcqua W, Wu H, Chowdhury PS (2015) Improving target cell specificity using a novel monovalent bispecific IgG design

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doi: 10.1182/blood-2006-05-026203 108 OricchioEKatanayevaNDonaldsonMCSungaleeSPasionJPBeguelinWet al