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Experimentally this is measured by comparing the Area-Under-the-Curve (AUC) of the drug when serial measurements of plasma concentration are made following oral administration compared to i.v

The most cited barrier by the transplant nurse coordinators was other responsibilities taking precedence (N=3), as well as a perception that transplant social workers are better suited to perform this task (N=5, open-ended responses)

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Moreover, despite the considerable pre-clinical efficacy of several pharmacological agents targeting pathological events of hemorrhagic stroke, they failed to perform in clinical trials as factors such as the short half-life periods of agents and the role of the blood-brain barrier (BBB) complicated the scenario (Grysiewicz et al., 2008)