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Another study demonstrated that the combination of CAR-T cells and modified OVs expressing TNF- and IL-2 has a robust anti-tumor effect in the pancreatic ductal adenocarcinoma (PDA) murine model [48]

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These findings show that AS3MT automethylation is governed by at least four cysteines C33, C62, C157, and C207, which are the same residues needed to catalyze arsenic methylation