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As a key part of the bodys endogenous defense mechanism, the presence of glutathione neutralizes and reduces these free radicals.* The production of ROS increases with age, at the same time our internal defense mechanisms weaken, resulting in oxidative stress an imbalance where ROS outnumber antioxidants in the body

Additionally, older people suffering from acute ischemic stroke were found to be deficient for riboflavin (118), and riboflavin deficiency has been linked to a higher risk of fracture in postmenopausal women with the MTHFR 677T variant (119)

Indeed, protein per-sulphidation is posited to confer a protection mechanism to prevent irreversible oxidation of protein cysteine residues

10.1249/JSR.0b013e31825dabb8 235 WilloughbyD