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The poly (ADP-ribose) polymerase olaparib has been demonstrated to promote ferroptosis in ovarian cancer cells by downregulating SLC7A11 expression (Hong et al., 2021)

Pol A, Renkema GH, Tangerman A, Winkel EG, Engelke UF, de Brouwer AM, et al

1GL), indicating that GSH inhibition is a key factor promoting the sensitivity of VRK2-deficient cells to APR-017 and LCS3

Additionally, drug repurposing can allow the revaluation of drugs that failed in the development phase for other uses and the change of application settings for better use ( 3.2 Methods of drug repurposing As high-throughput screening and computational biology methods advance, accumulated data lay the foundation for new approaches to rational drug repurposing (Turanli et al., 2021)