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John's, Canada, 2 University of Oxford, Oxford, United Kingdom, 3 Department of Medicine (Neurology), University of Toronto, Toronto, Canada, 4 Sunnybrook Health Sciences Centre, Toronto, Canada, 5 ICES, Toronto, Canada, 6 Kite Research Institute, UHN Toronto Rehabilitation Institute, Toronto, Canada, 7 Temerty Faculty of Medicine, Toronto, Canada, 8 GTA Rehab Network, Rehab Care Alliance, Toronto, Canada, 9 Hennick Bridgepoint Hospital, Sinai Health, Toronto, Canada Background and Aims: Previous studies demonstrate that higher admission volumes to acute stroke centres are associated with better patient outcomes

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Quantification of SAM and SAH confirmed the DZnep-dependent increase in SAH and resultant collapse of the methylation potential in cells transfected with mutant, but not wild-type MTAN (Fig

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