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Despite some progress in understanding its pathogenesis, the primary treatment remains surgery, with relatively poor treatment outcomes

doi: 10.1016/s0891-5849(99)00131-8

Ethical principles of the study complied with the European Directive 010/63/E, the Law on Amendments to the Animal Protection Act (Official Gazette 37/13), the Animal Protection Act (Official Gazette 135/06), the ordinance on the protection of animals used for scientific purposes (Official Gazette 55/13), Federation of European Laboratory Animal Science Associations (FELASA) recommendations, and the recommendations of the Ethics Committee of the School of Medicine, University of Zagreb

92 Endogenous enzymes (Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx)) and non-enzymatic molecules such as Reduced Glutathione (GSH), melatonin, and coenzyme Q10 (ubiquinone), aid in keeping free radicals in a homeostatic state