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The involvement of the IGF system as intraovarian regulators of folliculogenesis has been intensively studied in a variety of mammal species, and it is now established that the ovary is a site of IGF-I gene expression and reception[102]

Other sources of superoxide can be enzymatic reactions that transfer electrons to the ETC such as mitochondrial glycerol 3-phosphate dehydrogenase (mGPDH), and the last step of -oxidation, electron-trasferring flavoprotein ubiquinone oxidoreductase (ETFQOR) or dehydrogenases such as pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxoacid dehydrogenase (BCKDH)