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MiR-29b-3p cooperates with miR-29c-3p to affect the malignant biological behaviors in T-cell acute lymphoblastic leukemia via TFAP2C/GPX1 axis

Since such a first cycle arrest is typical for agents that break DNA 30 and because HANs were linked with DNA breaks in mammalian cells 10 , we tested whether they increase the phosphorylation of histone 2AX at S129 by Rad3 and Tel1, an established marker of chromosomal breaks 31