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Accumulation of mtDNA damage is particularly detrimental and has been implicated in the pathogenesis of NDDs such as AD, PD, HD, and ALS

Progesterone is also a substrate of the 5-reductase-2 isoenzyme, which converts it to dihydroprogesterone, a hormone that in turn competes with testosterone and DHT for the androgen receptor (12)

Whether pain management is best accomplished by the primary treating clinician and/or by a multidisciplinary team or other pain specialists should be determined by the individual clinician in consultation with the patient

Despite these limitations, this study validates the safety of combined cagrilintide and semaglutide pharmacotherapy, justifying additional studies to evaluate efficacy for weight management in obesity