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Research in PD animal models has shown that NPT200-11 reduces abnormal -syn accumulation, suppresses astrocytic activationthus attenuating neuroinflammationand normalizes striatal dopamine transporter (DAT) levels, alleviating motor deficits in PD mice [155]

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Analysis revealed that ACSL4 was also more highly expressed in PC-9 and NCI-H1975 cells, indicating a potentially greater sensitivity to lipid peroxidation triggered by intracellular ROS accumulation (Fig