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The rise of drug resistance impacts treatment outcome, and understanding its causes, spread, and impact will help us manage the risks it imposes (Moncada-Diaz et al., 2024)

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Peptide therapies like GLP-1, kisspeptin, tesamorelin, GH releasers, and BPC-157 can target appetite, insulin sensitivity, lipid metabolism, and reproductive hormone signaling

triggers Hormonal changes (especially during puberty, menstruation, or pregnancy), stress, certain medications, diet and genetics can all contribute to its development.