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Preliminary studies have shown that targeting GLO1 by small molecule inhibitors such as S-p-bromobenzylglutathione cyclopentyl diester (BBGC) significantly inhibits the growth and induces apoptosis of leukemia and other tumor cells, while reversing the resistance of cancer cells to chemotherapeutic drugs (103, 144, 152154)

This anti-inflammatory action is mediated through several signalling pathways, including the inhibition of the nuclear factor kappa B (NF-B) pathway, contributing to the reduction of liver inflammation associated with NAFLD

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doi: 10.26355/eurrev_202207_29194 165 WeiGZhouZCuiYHuangYWanZCheXet al