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To translate BPC157 into the clinic, we previously conducted preclinical safety studies and found that BPC157 was well tolerated and did not demonstrate serious toxicity ( We studied the pharmacokinetics of BPC157 after its IV and IM administration in rats and beagle dogs

Tripeptide in human plasma that prolongs survival of normal liver cells and stimulates growth in neoplastic liver. Nature New Biology , 243(124), 8587

Studies in IBD patients indicate that TNF levels are increased in the serum, stool, and intestinal mucosa [20] and, correspondingly, patients display increased intestinal paracellular permeability that is characterized by suppression and re-distribution of occludins, and claudins 5,8, whereas claudin-2 expression was upregulated [21]

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