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GSH biosynthesis by way of the gamma-glutamyl cycle is important for maintaining GSH homeostasis and normal redox status, this cycle can be seen in Fig

Because of the similarity in the pathomechanism of different SNHLs and the known DAergic [82], anti-apoptotic [24], anti-oxidant [25], neuroprotective [26] and immunmodulatory actions [27] of selegiline, we initiated a study on the effects of selegiline and its analogues on DA release from LOC terminals in the mouse cochlea and in an AGIHL mouse model

Huang X, Hui C, Chen Y, Chun B, Wong Y, Fung P, Metz C, Cho C, Hui W, Bucala R , Lam S, Lan H