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That is a very different statement from they do nothing. It means: The mechanistic rationale is real

Optimizing sleep and hormonal output helps maximize NAD-driven fat loss

2018 Oct 01;112(10):423-435

Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision