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Using the nude mice model with subcutaneous xenograft, a study found that 80% more zinc was detected in the tumors implanted with ZIP4 stably overexpressed MIA-ZIP4 cells compared with the normal group

In 1998 the cuprizone animal model experienced a comeback as the group of Matsushima (Hiremath et al., 1998) characterized cuprizone-induced de- and remyelination in the corpus callosum (CC) of C57BL/6 mice

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Although preclinical studies reveal GLP-1 receptor expression within reproductive tissues and possible direct mechanisms, current human data remain inconclusive