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Although these diseases develop from exposure to cigarette smoke, most of the toxic substances come from burning the tobacco leaves themselves

A mouth to lung vape mimics the draw of a traditional cigarette, where the vapour is first held in the mouth before being inhaled into the lungs

22 Exposure of alveolar macrophages (AMs) to a sublethal 0.5% EVC or nicotine-free ECVC (nfECVC) increases ROS production approximately 50-fold and significantly inhibits phagocytosis