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The role of tryptamine, indole and their derivate has been suggested in different psychiatric disorders, although little is known about their possible implication in BD [215]

As the body ages, its ability to produce glutathione decreases

Page KA, Williamson A, Yu N, McNay EC, Dzuira J, McCrimmon RJ, et al

One of these enzymes, HNMT, needs SAM to do its job.2 So, for HNMT to break down histamine properly, its important that the MTHFR enzyme is working well to support this process