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Importantly, as shown in the first row, LASSS supplementation effectively prevented an increase in the nitration level of ECM-HGF, whereas GSSSG did not demonstrate efficacy, inconsistent with its potent potential shown in in vitro experiments described earlier (see Figure 1b)

MSCs, for instance, have the ability to release substances that prevent ferroptosis, shielding lung cells from iron-dependent lipid peroxidation (89)

Thus, the discovery positions GGCT as a promising therapeutic target for disrupting metabolic plasticity through its dual roles in Gln shunting and Glc compensation