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Notably, basement membraneassociated extracellular matrix remodeling was closely associated with neuropathological alterations in AD

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The hallmark features of the subtype include higher expression of Ki67 (hence higher proliferation rate), lower expression of PR, and in some cases, positive status of HER2 and ER, a more aggressive phenotype with higher chances of early relapse, poor prognosis, lower survival rate, lymph node involvement, and metastasis ( 3.3 HER2 subtype This class of tumors is characterized by increased HER2 expression, while ER/PR expression is absent

Taken together, the structural information gleaned from our examination of the crystal structures revealed that loop 3 or the 2-helix loop is critical to the shape of the overall architectures of the ABSs in bacterial GUSs