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The most common vitamin B12 deficiency symptoms are: Fatigue Weakness Loss of appetite Weight loss Numbness and tingling in the hands and feet Soreness of the mouth or tongue A pale yellow tinge to your skin Difficulty maintaining balance Disturbed vision Depression Confusion Poor short-term memory A severe vitamin B12 deficiency can cause megaloblastic anemia, also known as vitamin B12 deficiency anemia, where red blood cells are not produced properly and are larger than normal

DNA synthesis and cell metabolism Intracellular conversion of vitamin B 12 to two active coenzymes, in mitochondria and adenosylcobalamin in the cytoplasm, is necessary for the homeostasis of methylmalonic acid and homocysteine, respectively

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