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SKU: 49301423196 · From composequickly.com

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Final Report of a Phase I TNFerade Biologic plus chemoradiotherapy prior to esophagectomy for locally advanced resectable esopahgeal cancer

[25] In human cells with mutant WRN, NAD+ repletion restored normal mitophagy, improved fat metabolism, decreased mitochondrial oxidative stress, and enhanced mitochondrial quality

Oxidative stress, inflammation, and mitochondrial dysfunction were identified in these brain regions, suggesting they are the root causes of the observed neurochemical and histopathological changes (Mazumder et al., 2019)