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Metabolomics studies have further demonstrated that EGCG exerts anti-lung cancer benefits by regulating 33 differential metabolites in A549 cells, which are involved in various metabolic processes including glucometabolic, amino acid metabolism, nucleotide metabolism, and vitamin metabolism [596, 597]

187 Reduction of insulin levels with diazoxide Diazoxide is a nondiuretic benzothiadiazine that has an antihypertensive effect and produces hyperglycemia via lowering insulin levels by activation of ATP-sensitive K + -channels, which have a key function in the control of insulin release

Iron chelators prevent the initiation of lipid peroxidation by inhibiting lipoxygenases (LOXs) and the propagation of lipid peroxidation by suppressing Fenton chemistry

Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype