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Structureactivity relationship of ENL-driven CRBN binding To evaluate the mechanism of CRBN engagement further, we assessed the dHTC1 structureactivity relationship (SAR) by replacing the sulfamide connection with an amide, yielding rac -dHTC1-amide ( 5 ), or with a urea, yielding rac -dHTC1-urea ( 6 )

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These results are more generally consistent with other findings suggesting that the SMA and anterior cingulate have strong reciprocal connections that act to sustain each others activity, and that this interaction is mediated during movement preparation according to the readiness potential amplitude 57 , which is enhanced in OCD 72