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While the physiological impact of elevated CRP has not as yet been fully resolved 14,27 , elevated fibrinogen levels are thought to lead to platelet aggregation, increased blood viscosity, thrombosis and CVD, in part via its conversion into fibrin during blood coagulation 8,13

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Ailsa Rutter, Director of Fresh, which supported the introduction of the approach across the region said: These findings and the drastic decline in smoking in pregnancy in the North East by around a third since 2009 shows the vital role the NHS can play in reducing harm from tobacco