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The total daily dose of one or both of the pharmaceutically active compounds may be administered in single or divided doses and may, at the physician's discretion, fall outside of the typical range given herein e.g., in order to cope with the needs of a patient subpopulation to be treated or the needs of the single patient which different needs can be due to the particular disease, severity of the disease, age, sex, or body weight as can be readily determined by a person skilled in the art

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Evening routine design Create a 30-60 minute wind-down routine that signals to the body and brain that sleep is approaching

Their cells are already highly insulin-sensitive, and their system is resilient