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However, a case-by-case analysis of the involved toxicants in each patient did not show pertinent drug-drug interactions that could have altered VPA metabolism or elimination

J Biol Chem 265:1291612926 Richards EM, Rosenthal RE, Kristian T, Fiskum G (2006) Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity

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Hierarchical clustering analyses showed an association between brain IR and specific clinical symptoms, with the highest levels of IRS-1 in L1CAM exosomes associated with suicidality, anhedonia, depressed mood and feelings of guilt