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During aging, the GSH system in general and the GPx family in particular undergo modifications that promote the production of oxidative stress resulting in disturbances in metabolic regulation, damage of cellular constituents accompanied by cardiovascular follow-up, neurodegeneration, and cancers

A reduced gut microbial diversity and altered microbiota composition is observed in obese individuals

Furthermore, metformin has been shown to improve endometrial tolerance through its actions on the mitochondrial respiratory chain, activation of AMPK, suppression of NF-B, AGE production, and downregulation of inflammatory pathways (Jinno et al., 2021)

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