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The prevalence of a distinct prodrome phase is not entirely clear because studies have reported differing rates, but a significant portion of migraineurs indicate that they experience symptoms that predict the onset of migraine

doi: 10.3389/fimmu.2017.00233 64 PocaterraLJainSReddyRMuzaffarullahSTorresOSuneethaSet al

10.1007/s12072-010-9204-4 69

The treatment response needs to be verified by two objective criteria: (1) Immunohistochemistry or qRT-PCR confirms the restoration of NIS/TSHR protein and mRNA expression