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Transcriptional repression of PGC-1 by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration

Characterized by an acute reduction of arterial blood supply to the brain, DCI is dependent on the severity of the initial aneurysm, early brain pathologies, and the development of cerebral vasospasm (CV), though other factors such as microvascular spasm and micro-thrombosis have been considered contributary [9, 10]

Cell lines, tissues, and cell culture GSC lines (387, 4121, 3691, 3832, 456, and H2S GSCs) were derived by our laboratory and transferred via a material transfer agreement from Duke University (Durham, NC) and were functionally characterized 20,21,44,45

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