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A 2014 study suggests that maintaining health, shielding the body from toxins, and promoting longevity require adequate glutathione availability

In addition, significant beneficial changes in the composition and abundance of intestinal microbiota were observed in mice after NMN treatment [70]

Targeting to and/or across blood-tissue barriers In another aspect of the invention, a method of targeted drug delivery of an effective amount of an agent, or a pharmaceutical acceptable carrier comprising an agent, to a target site that is protected by a specific blood-tissue barriers like e.g., the CNS, the blood-brain barrier (BBB), the retina and the testes, is provided wherein: a) the agent or the pharmaceutical acceptable carrier is conjugated to a ligand, that facilitates the specific binding to and internalization by an internalizing GSH uptake receptor of the target site, thereby forming the conjugate as defined above