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Following successful model induction, the Uricase and RBC@SeMSN@Uri groups received intravenous injections of 10 mg/kg Uricase or RBC@SeMSN@Uri at 0 h, coinciding with the cessation of fructose feeding

In addition to the direct effects of altered glutamine consumption on the function of immune cells and glutamine metabolism in the TME, the functional changes in the tumor cells themselves also directly affects the anti-tumor response