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Pain decreases, stiffness loosens, and sleep improves

193 Another study also found that patients with higher baseline gut flora -diversity respond better to immunotherapy, and a machine learning classifier based on serum metabolites performed better (AUC 0.793) than a classifier based on gut flora in predicting potential beneficiaries of immunotherapy

And many symptoms overlap with other conditions

It might be argued that for the long time scale of PD progression, apoptosis is an acute cellular event that on the surface does not perfectly explain the development of PD, but when patients start to have detectable parkinsonism symptoms, there is usually at least 4060% dopaminergic neuronal loss in the substantia nigra ( c do not mean that it releases cyt c and activate caspases immediately