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In some contexts it is suggested that it could support mitochondrial function or neuronal signalling, but the clinical evidence is heterogeneous and does not allow generalisation of benefits to the whole population

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2,97 Studies and clinical practice of treatment of pernicious anaemia with regular high-dose injections has confirmed the safety of B12 at high dosages, and therefore neither the Institute of Medicine (IOM) in the USA nor the European Food Safety Agency (EFSA) have set an upper limit

Enzyme stability The cyclic disulfide bond structure makes it less likely to be degraded by proteases in adipose tissue, prolonging the action time