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Post-procedure pain: 2-5/10 (soreness, stiffness, warmth) Increased pain and swelling at injection site Initial flare expected in 60-70% of patients Pain during injection: 2-4/10 Bone marrow harvest (if combined): 3-6/10 Can Pain Get Worse Before It Gets Better After PRP

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An oligonucleotide of step (b) can further comprise a nucleic acid sequence capable of introducing one or more nucleotide residues into the template polynucleotide, or, deleting one or more residue from the template polynucleotide