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Conformational change in the ligand-binding domain has been a basic requirement for the construction of FRET-based nanosensors, and also for translating metabolite binding into a change in FRET 26

I hadn't realized how impossible this research is until I read some of Alessio Fasano's research (Mass General

DMT1, a member of solute carrier family 11 member 2 (SLC11A2), plays a role in iron transport, and its expression would be increased if exposed to high-iron environment