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This modification positively regulates PARP1 recruitment to sites of DNA damage and augments its enzymatic activity in response to oxidative stress [45] (Figure 4A)

Furthermore, it alters the nucleic acid composition by reacting selectively with deoxyguanosine [43]

V.SukasemC.CanyukB.PattharachayakulS

After adjustment for age, sex, hypertension, diabetes, atrial fibrillation and smoking, white matter hyperintensity burden was not significantly associated with poor collaterals (OR 1.278, 95% CI 0.742 2.201, p = 0.376) in regression analysis