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Description

Following menopause, the lack of estrogen stimulation causes the myometrium and endometrium to undergo significant atrophy, resulting in a much smaller uterine volume

The findings reveal a novel regulatory mechanism of deubiquitinase USP33 in controlling the magnitude of PRKN-mediated mitophagy process, and offer the important insights into dynamic balance of ubiquitination and deubiquitination in the maintenance of mitochondrial self-homeostasis

This study was reviewed by the Institutional Review Board of the Boston University School of Medicine and was approved for exemption because it only included tissues collected from post-mortem subjects not classified as human subjects