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One Cochrane review found that high-dose oral vitamin B12 supplements (1,000 mcg to 2,000 mcg per day) was as effective for correcting megaloblastic anemia as B12 shots

Each vial has its own reconstitution date, and combining them creates uncertainty about the total peptide content and the effective expiration date

This makes individuals with kidney conditions a special population where the blanket safety of high-dose supplements may not apply uniformly

Why its hard to say how often serious side effects happen One frustrating reality is that precise incidence rates for many B12 injection complications are not well defined