ABBREVIATIONS 6-MP 6-mercaptopurine 6-TG 6-thioguanine (6-mercaptopurine and 6-thioguanine) CAO 4-[N-(S-cysteinylacetyl)amino]phenylarsonous acid cAVTP cis-6-(2-acetylvinylthio)-purine CPIC p-chlorophenyl isocyanate DMAC dimethylarsino-cysteine DMACG dimethylarsino-cysteinylglycine EGFR epidermal growth factor receptor GSH glutathione GCAO 4-[N-(S-cysteinylglycylacetyl) amino] phenylarsonous acid GT gamma-glutamyl transferase GSAO [4-(N-(S-glutathionylacetyl) amino)phenylarsonous acid] GS-cAVTP glutathione s-cis-6-(2-acetylvinylthio)-purine Glu glutamate Gly glycine GS-tAVTG glutathione s-trans-6-(2-acetylvinylthio)-guanine PENAO 4-(N-(S-penicillaminylacetyl)-amino)phenylarsonous acid SCPG S-(N-pchlorophenylcarbamoyl) glutathione tAVTG trans-6-(2-acetylvinylthio)-guanine
Significant progress has been made in constructing GSH-responsive drug delivery systems (DDSs) capable of site-specific therapeutic release within the tumor microenvironment [15]
doi: 10.3389/fcell.2025.1611055 Received 13 April 2025 Accepted 02 June 2025 Published 16 July 2025 Volume 13 - 2025 Edited by Rosa Vona, National Institute of Health (ISS), Italy Reviewed by Sidra Islam, Case Western Reserve University, United States Sajal Sen, Massachusetts Institute of Technology, United States Updates Copyright 2025 Qi, Mu, Hu, Li and Liu
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