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Nonetheless, the use of melatonin needs cautionary measures when used with other medications, especially anticoagulants such as warfarin, since their interaction could increase the risk of bleeding [220,221,222] To show the variability of its pathological involvement, melatonin is implicated in sleep disorders [223, 224], precocious puberty [225], polycystic ovary syndrome, endometriosis [226], coronary heart diseases [227], GIT disorders [228], cancer [229], diabetes [230], obesity and energy metabolism issues [231], and a wide array of psychiatric and neurological disorders [232]

Some of these tissues and cells will be phagocytized, absorbed, and degraded by peritoneal macrophages and stored in the form of haemosiderin

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