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Multiple mechanisms are responsible for the anemia, but the main mechanisms are decreased RBC production due to suppression of erythropoiesis, reduced iron availability, and decreased RBC lifespan (extravascular hemolysis)

Chronic altitude illness CMS Unlike acute altitude illnesses, research on the genetic basis of CMS is limited, with only a few studies exploring the link between CMS susceptibility and several genes, including SENP1 , ACE , AGT , and VEGFA (Table 1)

HIV replication depends on the activation of NF-B [70]

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