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Given the unlicensed status of retatrutide in the UK and the complexity of injectable peptide reconstitution, seeking qualified medical advice before any use is strongly recommended and in many circumstances, essential

A phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) reported substantial weight loss and improvements in glycaemic parameters, though the trial was conducted in a closely monitored clinical setting with defined eligibility criteria

The microscopy images showed cell rupture and lysis (H&E stain), indicative of signs of cell death (TUNEL stain) in the tumor tissue (Fig

Ethics declarations Ethics approval and consent to participate All animal studies were ethically reviewed and carried out in accordance with European Directive 2010/63/EEC and Swedish legislation on animal experiments (SJVFS 2019:9)