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Patients should administer three injections together at the start of the cluster period and may repeat this dose monthly until the cluster period ends

In addition, whether the absorption, distribution, metabolism, and excretion as well as the blood concentration of coral change over time after administration in the body remains unclear

Urine samples collected for the measurement of F 2 -IsoPs were stored at 80C prior to shipment to Vanderbilt Eicosanoid Core Laboratory (Nashville, Tennessee, USA) for quantification of F 2 -IsoPs F 2 (PGF 2 ), free 8-iso-prostaglandin F 2 (8-iso-PGF 2 ), 2,3-dinor-5,6-dihydro-15-F 2t -IsoP and 5-series F 2 -IsoP by GC-negative ion chemical ionisation-MS employing stable isotope dilution as described in Milne et al