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Dose-response relationships: Biological effects show threshold (minimum effective concentration), linear response zone (increasing dose produces proportional benefits), and saturation (maximum benefit reached, further increases provide minimal additional effect)

This review highlights the importance of glutamine metabolism in AML cells and addresses potential related strategies for AML treatment, including depletion of systemic glutamine and application of glutamine uptake inhibitors, glutamine antagonists/analogues, and glutaminase inhibitors