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Abbreviations CAP: Community-acquired pneumonia HAP : Hospital-acquired pneumonia VAP: Ventilator-associated pneumonia HCAP: Healthcare-associated pneumonia COPD: Chronic obstructive pulmonary diseases ICU: Intensive care unit ROS: Reactive oxygen species DNA: Deoxyribonucleic acid IL-6: Interleukin-6 IL-8: Interleukin-8 IL-1 : Interleukin-1 eta TNF- : Tumor necrosis factor alpha ARDS: Acute respiratory distress syndrome SIRS: Systemic inflammatory response syndrome NAC: N-acetylcysteine CoQ10: Coenzyme Q10 ATP: Adenosine triphosphate NF-KB: Nuclear factor kappa B A549 cell lines : Adenocarcinomic human alveolar basal epithelial cells BEAS-2B: Human non-tumorigenic lung epithelial cell line derived from a human lung tissue COVID-19: Severe acute respiratory syndrome coronavirus 2 (SARS-cov-2) CT: Computed tomography ASX: Astaxanthin Se: Selenium GPX1: Glutathione peroxidase RSV: Respiratory syncytial virus SOD: Superoxide dismutase 6MWT: 6-Minute walk test ADL: Activities of daily living questionnaire ICAM-1: Intercellular adhesion molecule-1 SOFA score: The sequential organ failure assessment score CPIS: Clinical pulmonary infection score PICU: Pediatric intensive care unit ALRI: Acute lower respiratory tract infection URTI: Upper respiratory tract infection LRTI: Lower respiratory tract infection MDA: Malondialdehyde TAOC: Total antioxidant capacity nsMPP : Non sever mycoplasma pneumoniae pneumonia sMPP: Sever mycoplasma pneumoniae pneumonia References Shi T, Denouel A, Tietjen AK, Lee JW, Falsey AR, Demont C, Nyawanda BO, Cai B, Fuentes R, Stoszek SK (2020) Global and regional burden of hospital admissions for pneumonia in older adults: a systematic review and meta-analysis

The ACSL4 signaling pathway is known to contribute to cell death by inducing ferroptosis [46, 47]