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Recovery of neurologic dysfunction with early intervention of vitamin B12 While red blood cells complete their regeneration cycle every 90 days, fully resolving a vitamin B12 deficiency involves more than just blood cell renewal

As the folate promotes the oligodendrocyte survival and myelination through DHFR-AMPK axis [51], therefore, folate deficiency, by impairing this DHFR-AMPK axis, can promote MS development or progression by negatively affecting oligodendrocyte survival and myelin production